7:00 am - 8:00 am
Sponsored by Johnson's BABY
7:30 am – 8:30 am
CASES OF THE YEAR: PART I
9:00 am – 10:30 am
COURSE 1: Pigmentary Disorders in Children
Nanette Silverberg, Icahn School of Medicine, USA
Alain Taieb, Universite de Bordeaux, France (chairs)
This course will feature international speakers who will address pertinent topics in the clinical identification, diagnosis and therapy of pigmentation in childhood. Topics to be reviewed include the differences between congenital and acquired hypopigmentation and the diagnostic features for acquired hyper- and hypopigmenting disorders, with a specific focus on children of color, who represent 70% of the worldwide population. Specific topics that will be addressed include albinism, vitiligo, progressive macular hypomelanosis, idiopathic eruptive macular pigmentation, erythema dyschromicum perstans, congenital nevi, and Blaschkoid pigmentation in early childhood. Therapeutic topics will include the usage of treatments for repigmentation and removal of pigmented birthmarks including cafe au lait macules, nevus of Ota and melanocytic nevi using laser technology.
SYMPOSIA 1: An Update on Primary Immunodeficiencies and Infectious Complications
Carrie Coughlin, Washington University School of Medicine, USA
Arti Nanda, As'ad Al-Hamad Dermatology Center, Kuwait (chairs)
Primary immunodeficiency disorders (PIs) are genetic, heterogeneous disorders that affect distinct components of the innate and adaptive immune system. They are difficult to diagnose and manage, and can cause marked morbidity and mortality. Recently, advances in molecular genetics and immunology have resulted in identification of more than 200 different PIs and provided insight into the basic pathophysiology of these disorders. These advancements have contributed to improved supportive care and treatments including biologics, hematopoietic stem cell transplant (HSCT), and gene therapies. Similar to patients with iatrogenic immunocompromise, these patients can have serious complications throughout their courses.
SYMPOSIA 2: Superficial and Deep Fungal Infections
Sheila Fallon Friedlander, UCSD/Rady Children's Hospital, USA
Hector Caceres-Rios, Instituto De Salud Del Nino, Peru (chairs)
This symposium will review fungal infections of particular concern in the pediatric population. The latest diagnositic and therapeutic advances will be presented, including best practices for the teatment of tinea capitis and new diagnositic methods and treatments for pediatric onychomycosis. Serious cutaneous and systemic fungal infections in the newborn period are an increasing concern, particularly in the premature population, and will be reviewed, as will systemic and opportunistic infections in pediatric patients.
SYMPOSIA 3: Epidermolysis Bullosa: What Has Changed, What Does the Future Hold?
Anna Bruckner, Children's Hospital Colorado, USA
Francis Palisson, Universidad Del Desarrollo, Chile (chairs)
The blistering disorder, epidermolysis bullosa (EB), while rare, can be devastating due to its significant impact on skin integrity, overall health, and quality of life for the affected patient and his/her family. Advances in molecular medicine and research are tranforming the approach to EB. In this session, international EB experts will discuss the state-of-the-art for EB, including how to approach diagnosis, management, and a team-based approach to care.
10:30 am – 11:00 am
11:00 am – 12:30 pm
COURSE 1: Pigmentary Disorders in Children – continued
SYMPOSIA 4: Autoinflammatory Syndromes: Diseases Rare and Not so Rare
Kieron Leslie, University of California San Francisco, USA
Karoline Krause, Charité, Germany (chairs)
Autoinflammation is characterized by aberrant regulation of the innate immune system and often manifests as periodic fevers and systemic inflammation involving multiple organs, including the skin. Mutations leading to abnormal behavior or activity of the interleukin 1 beta (IL-1ß)-processing inflammasome complex have been found in several rare autoinflammatory syndromes, for which anticytokine therapy such as IL-1 or tumor necrosis factor-alfa inhibition may be effective. It is becoming clear that features of autoinflammation also affect common dermatoses, some of which were previously thought to be solely autoimmune in origin (e.g., vitiligo and systemic lupus erythematosus). Recognizing the pathogenetic role of autoinflammation can open up new avenues for the targeted treatment of complex, inflammatory dermatoses.
SYMPOSIA 5: Congenital and Spitz Nevi and Melanoma in Children
Elena Hawryluk, Massachusetts General Hospital, Harvard Medical School, USA
Veronica Kinsler, Great Ormond St Hospital for Children, UK (chairs)
This session will present an overview of pediatric pigmented neoplasms, from congenital melanocytic nevi to Spitzoid tumors and pediatric melanoma. The case-based format will promote an active learning environment relevant to both the dermatology trainee and experienced clinician, and experts from around the world will address challenges in the management of these patients. The session will offer practical tips for the evaluation, diagnosis, and treatment of pediatric pigmented lesions.
SYMPOSIA 6: Lymphatic and Venous Malformations
Catherine McCuaig, University of Montreal, Canada
Mikka Vikkula, de Duve Institute, Université Catholique de Louvain, Belgium (chairs)
The attendee will be provided with an update of the genetic basis for lymphatic and venous malformations, and pathophysiology and function of lymphatics in normal state and disease. The diagnosis, investigation and management of microcystic and macrocystic lymphatic malformations and lymphedema will be discussed. The diagnosis, investigation and treatment of venous malformations with emphasis on the associated coagulopathy will be highlighted.
12:30 pm – 2:00 pm
Satellite Symposia & Lunch on Own
2:00 pm – 3:30 pm
COURSE 2: Collagen Vascular Disorders: Integrating Research into Clinical Care
Yvonne Chiu, Medical College of Wisconsin, USA
Zigang Xu, Beijing Children's Hospital, Capital Medical University, China (chairs)
Collagen vascular disorders are multisystem autoimmune diseases that often have cutaneous manifestations. Pediatric dermatologists are frequently involved in the care of these complex patients but may be challenged by the rarity of these disorders, atypical clinical presentations, or management conundrums. Additionally, there are important distinctions that differentiate pediatric collagen vascular disorders from those in adults. This symposium will provide the latest research-driven updates on the most common collagen vascular disorders encountered by a pediatric dermatologist, including cutaneous lupus erythematosus, juvenile dermatomyositis, vasculitis, and morphea. Challenging cases will also be presented to highlight rare and atypical clinical scenarios, and practical tips will be offered on the use of commonly-prescribed systemic medications.
SYMPOSIA 7: Abuse and Factitial Disease
Lawrence Schachner, University of Miami, USA
Ramon Grimalt, Universitat Internacional de Catalunya, Spain (chairs)
Child abuse and neglect, sexual abuse, and factitial injuries affect over 3 million children annually in the USA. That number is multiplied multifold worldwide. Environmental injuries to children’s skin exceeds those in number. This symposium will provide in depth education on these important issues.
SYMPOSIA 8: Cutaneous Manifestations of Endocrine Disorders in Children
Anne Lucky, Cincinnati Children's Hospital, USA
Eli Sprecher, Tel Aviv Sourasky Medical Center, Israel (chairs)
This symposium will cover various aspects of hormonal interactions in the skin. There will be a review of syndromic genodermatoses such as Carney complex, multiple endocrine neoplasias, autoimmune polyendocrinopathies, and Albright osteodystrophy. Disorders featuring androgen excess causing acne, hirsutism and androgenetic alopecia, including polycystic ovary syndrome, congenital adrenal hyperplasia and tumors, will be reviewed and mechanisms of androgen actions on the skin discussed. Finally there will be a presentation about some of the controversies surrounding the role of vitamin D as related to skin disorders.
SYMPOSIA 9: Advances in Ichthyoses & Ichthyosis Syndromes
Keith Choate, Yale University School of Medicine, US
Heiko Traupe, University Hospital Muenster, Germany (chairs)
The aim of this symposium is to acquaint pediatric dermatologists with recent advances in the field of molecular diagnosis of ichthyosis, to familiarize attendees with the manifold practical problems that occur in the spectrum of peeling skin diseases (which encompas various disorders associated with skin peeling and allergic manifestations), and to review treatment for newborns and older children with congenital ichthyosis.
3:30 pm – 4:00 pm
4:00 pm – 5:30 pm
COURSE 2: Collagen Vascular Disorders: Integrating Research into Clinical Care – continued
SYMPOSIA 10: Updates on Hereditary Disorders of Elastic and Collagen Fibers (Pseudoxanthoma Elasticum, Cutis Laxa, Ehlers-Danlos Syndromes and Marfan Syndrome)
Jonathan Dyer, University of Missouri, USA
Ludovic Martin, Angers University Hospital, France (chairs)
Pseudoxanthoma elasticum (PXE), cutis laxa (CL), Ehlers-Danlos (EDS) and Marfan syndromes are hereditary disorders of elastic and collagen fibers. Each of these groups of disorders exhibits characteristic skin changes, even in childhood, which must be recognized by dermatologists and pediatricians. Recently, enormous progress in understanding these conditions has occurred. This session will succinctly review these disorders, focusing on critical clinical findings in childhood and state of the art updates regarding their evaluation and management, and highlight cutting edge advances in therapy.
SYMPOSIA 11: Inpatient and Critical Care Dermatology
Daniela Kroshinsky, Harvard Medical School/ Massachusetts General Hospital, USA
Jose Massimo, Latin American Society of Pediatric Dermatology - Argentine Association of Pediatric Dermatology, Argentina (chairs)
Inpatient dermatology provides an opportunity to longitudinally manage complex cases in pediatric dermatology and the dermatologist is an important member of the team caring for hospitalized children. This session will examine several challenging clinical scenarios in a case-based format and provide the attendee with an understanding of current and evolving standards of care. Common serious problems and their uncommon manifestations will be discussed. Interesting and rare examples of severe skin conditions will be presented. Valuable diagnostic and therapeutic interventions will be reviewed. This session is geared toward physicians caring for inpatients as well as treating complex patients presenting to the office.
SYMPOSIA 12: Evidence Based Management of Pediatric Psoriasis
Kelly Cordoro, University of California San Francisco, USA
Marieke Seyger, Radboud University Nijmegen Medical Centre, Netherlands (chairs)
Evidence-based practice integrates clinical expertise and high quality research evidence into the decision making process. Optimal management of pediatric psoriasis therefore requires a combination of up-to-date knowledge of the best available evidence, clinical experience, consideration of family preferences and understanding of disease impact on quality of life. In this symposium, international experts will summarize current evidence and offer their clinical expertise on genetic discoveries, potential comorbidities, use of conventional systemic treatments and biologic therapies relevant to the care of childhood psoriasis.