Friday, July 7

7:30 am – 8:30 am
CASES OF THE YEAR: PART I

9:00 am – 10:30 am

COURSE 1: Pigmentary Disorders in Children
Nanette Silverberg, Icahn School of Medicine, USA
Alain Taieb, Universite de Bordeaux, France (chairs)

This course will feature international speakers who will address pertinent topics in the clinical identification, diagnosis and therapy of pigmentation in childhood. Topics to be reviewed include the differences between congenital and acquired hypopigmentation and the diagnostic features for acquired hyper- and hypopigmenting disorders, with a specific focus on children of color, who represent 70% of the worldwide population. Specific topics that will be addressed include albinism, vitiligo, progressive macular hypomelanosis, idiopathic eruptive macular pigmentation, erythema dyschromicum perstans, congenital nevi, and Blaschkoid pigmentation in early childhood. Therapeutic topics will include the usage of treatments for repigmentation and removal of pigmented birthmarks including cafe au lait macules, nevus of Ota and melanocytic nevi using laser technology.

  • Congenital Generalized Hypopigmentation
    Kin-Fon Leong, Kuala Lumpur General Hospital, Malaysia
  • Acquired Hypopigmentation
    Nanette Silverberg, Icahn School of Medicine at Mount Sinai, USA
  • Disorders of Hyperpigmentation
    Carola Duran-McKinster, National Institute of Pediatrics, Mexico
  • Pigment Lasers
    Yong-Kwang Tay, Changi General Hospital and National University of Singapore, Singapore
  • Pigmentary Nevi
    Maria Boente, Hospital del Niño Jesus, Argentina
  • Childhood Vitiligo
    Rashmi Sarkar, Maulana Azad Medical College and Lok Nayak Hospital, India

SYMPOSIA 1: An Update on Primary Immunodeficiencies and Infectious Complications
Carrie Coughlin, Washington University School of Medicine, USA
Arti Nanda, As'ad Al-Hamad Dermatology Center, Kuwait (chairs)

Primary immunodeficiency disorders (PIs) are genetic, heterogeneous disorders that affect distinct components of the innate and adaptive immune system. They are difficult to diagnose and manage, and can cause marked morbidity and mortality. Recently, advances in molecular genetics and immunology have resulted in identification of more than 200 different PIs and provided insight into the basic pathophysiology of these disorders. These advancements have contributed to improved supportive care and treatments including biologics, hematopoietic stem cell transplant (HSCT), and gene therapies. Similar to patients with iatrogenic immunocompromise, these patients can have serious complications throughout their courses.

  • Skin Signs of Primary Immunodeficiencies: An Overview and What’s New?
    Arti Nanda, As'ad Al-Hamad Dermatology Center, Kuwait
  • Hyper IgE Syndromes: A New Outlook
    Christine Bodemer, Hopital Necker Universite Paris, France
  • Chronic Mucocutaneous Candidiasis: IL-17, Autoimmunity, and Related Disorders
    Julie Schaffer, Hackensack University Medical Center, USA
  • Opportunistic Infections in Immunosuppressed and Immunocompromised Children
    James Treat, Children's Hospital of Philadelphia, USA

SYMPOSIA 2: Superficial and Deep Fungal Infections
Sheila Fallon Friedlander, UCSD/Rady Children's Hospital, USA
Hector Caceres-Rios, Instituto De Salud Del Nino, Peru (chairs)

This symposium will review fungal infections of particular concern in the pediatric population. The latest diagnositic and therapeutic advances will be presented, including best practices for the teatment of tinea capitis and new diagnositic methods and treatments for pediatric onychomycosis. Serious cutaneous and systemic fungal infections in the newborn period are an increasing concern, particularly in the premature population, and will be reviewed, as will systemic and opportunistic infections in pediatric patients.

  • Tinea Capitis in Children - An Update
    Sheila Fallon Friedlander, UCSD/Rady Children's Hospital, USA
  • Treatment of Pediatric Onychomycosis
    TBD
  • Opportunistic Mycoses in Children
    Maria Victoria Dizon, Makati Medical Center, Philippines
  • Systemic Mycoses
    Alejandro Bonifaz, Hospital General de México, Mexico
  • Fungal Infections in the Neonate
    Lucia Diaz, Dell Children's Hospital, University of Texas Dell Medical School, USA

SYMPOSIA 3: Epidermolysis Bullosa: What Has Changed, What Does the Future Hold?
Anna Bruckner, Children's Hospital Colorado, USA
Francis Palisson, Universidad Del Desarrollo, Chile (chairs)

The blistering disorder, epidermolysis bullosa (EB), while rare, can be devastating due to its significant impact on skin integrity, overall health, and quality of life for the affected patient and his/her family. Advances in molecular medicine and research are tranforming the approach to EB. In this session, international EB experts will discuss the state-of-the-art for EB, including how to approach diagnosis, management, and a team-based approach to care.

  • Diagnosis of EB - Biopsy versus DNA Sequencing?
    Marcel Jonkman, UMCG, Netherlands
  • Monitoring and Management in RDEB
    Jemima Mellerio, St John’s Institute of Dermatology, UK
  • Cell-, Protein- and Gene-Based Therapies for EB
    Jakub Tolar, University of Minnesota, USA
  • Building a Multidisciplinary EB Team
    Francis Palisson, Universidad Del Desarrollo, Chile

10:30 am – 11:00 am
Break

11:00 am – 12:30 pm

COURSE 1: Pigmentary Disorders in Children – continued

SYMPOSIA 4: Autoinflammatory Syndromes: Diseases Rare and Not so Rare
Kieron Leslie, University of California San Francisco, USA
Karoline Krause, Charité, Germany (chairs)

Autoinflammation is characterized by aberrant regulation of the innate immune system and often manifests as periodic fevers and systemic inflammation involving multiple organs, including the skin. Mutations leading to abnormal behavior or activity of the interleukin 1 beta (IL-1ß)-processing inflammasome complex have been found in several rare autoinflammatory syndromes, for which anticytokine therapy such as IL-1 or tumor necrosis factor-alfa inhibition may be effective. It is becoming clear that features of autoinflammation also affect common dermatoses, some of which were previously thought to be solely autoimmune in origin (e.g., vitiligo and systemic lupus erythematosus). Recognizing the pathogenetic role of autoinflammation can open up new avenues for the targeted treatment of complex, inflammatory dermatoses.

  • Autoinflammation: A Molecular Primer
    Haley Naik, University of California San Francisco, USA
  • Autoinflammatory Clinical Syndromes
    Karoline Krause, Charité, Germany
  • PFAPA to CANDLE and Beyond
    Antonio Torrelo, Hospital del Nino Jesus, Spain
  • Common Skin Diseases and Autoinflammation
    Kieron Leslie, University of California San Francisco, USA

SYMPOSIA 5: Congenital and Spitz Nevi and Melanoma in Children
Elena Hawryluk, Massachusetts General Hospital, Harvard Medical School, USA
Veronica Kinsler, Great Ormond St Hospital for Children, UK (chairs)

This session will present an overview of pediatric pigmented neoplasms, from congenital melanocytic nevi to Spitzoid tumors and pediatric melanoma. The case-based format will promote an active learning environment relevant to both the dermatology trainee and experienced clinician, and experts from around the world will address challenges in the management of these patients. The session will offer practical tips for the evaluation, diagnosis, and treatment of pediatric pigmented lesions.

  • Congenital Melanocytic Nevi - What's New?
    Veronica Kinsler, Great Ormond St Hospital for Children, UK
  • Neurological Abnormalities Associated with Congenital Melanocytic Nevi
    Yasmin Khakoo, Memorial Sloan Kettering Cancer Center, USA
  • What's the Latest on Surgical Management of Large and Giant Congenital Melanocytic Nevi?
    Bruce Bauer, NorthShore University Health System, USA
  • Pediatric Spitz Nevus Conundrum - A Clinician's View
    Ashfaq Marghoob, Memorial Sloan Kettering Cancer Center, USA
  • Pediatric Melanoma Update
    Elena B. Hawryluk, Massachusetts General Hospital, Harvard Medical School, USA

SYMPOSIA 6: Lymphatic and Venous Malformations
Catherine McCuaig, University of Montreal, Canada
Mikka Vikkula, de Duve Institute, Université Catholique de Louvain, Belgium (chairs)

The attendee will be provided with an update of the genetic basis for lymphatic and venous malformations, and pathophysiology and function of lymphatics in normal state and disease. The diagnosis, investigation and management of microcystic and macrocystic lymphatic malformations and lymphedema will be discussed. The diagnosis, investigation and treatment of venous malformations with emphasis on the associated coagulopathy will be highlighted.

  • Genetic Basis of Lymphatic and Venous Malformations
    Mikka Vikkula, de Duve Institute, Université Catholique de Louvain, Belgium
  • Lymphedema and Lymphatic Malformation: Growing Insights into Normal Lymphatic Function and Pathogenesis of Disease
    Stanley Rockson, Stanford Center for Lymphatic and Venous Disorders, USA
  • Lymphatic Malformations and Lymphedema: Diagnosis, Therapy, Complications, and Outcomes
    Annabel Maruani, University François-Rabelais, France
  • Venous Malformations: Pathophysiology, Diagnosis, Syndromes
    Deepti Gupta, University of Washington School of Medicine, USA
  • Coagulation Abnormalities in Venous Malformations: Pathophysiologic Issues, Clinical Manifestations and Management
    Olivia Boccara, Hôpital Necker-Enfants Malades, France

12:30 pm – 2:00 pm
Satellite Symposia & Lunch on Own

2:00 pm – 3:30 pm

COURSE 2: Collagen Vascular Disorders: Integrating Research into Clinical Care
Yvonne Chiu, Medical College of Wisconsin, USA
Zigang Xu, Beijing Children's Hospital, Capital Medical University, China (chairs)

Collagen vascular disorders are multisystem autoimmune diseases that often have cutaneous manifestations. Pediatric dermatologists are frequently involved in the care of these complex patients but may be challenged by the rarity of these disorders, atypical clinical presentations, or management conundrums. Additionally, there are important distinctions that differentiate pediatric collagen vascular disorders from those in adults. This symposium will provide the latest research-driven updates on the most common collagen vascular disorders encountered by a pediatric dermatologist, including cutaneous lupus erythematosus, juvenile dermatomyositis, vasculitis, and morphea. Challenging cases will also be presented to highlight rare and atypical clinical scenarios, and practical tips will be offered on the use of commonly-prescribed systemic medications.

  • Cutaneous Lupus Erythematosus: How to Manage and When to Worry
    Heather Brandling-Bennett, Seattle Children's Hospital, USA
  • What’s New in Juvenile Dermatomyositis?
    Megan Curran, Ann & Robert H. Lurie Children's Hospital of Chicago, USA
  • A Vasculitis Update for the Pediatric Dermatologist
    Eulalia Baselga, Hospital de la Santa Creu i Sant Pau, Spain
  • Morphea: Beyond the Skin
    Yvonne Chiu, Medical College of Wisconsin, USA
  • Systemic Medications for Collagen Vascular Disease: Immunosuppressants and Beyond
    Megha Tollefson, Mayo Clinic, USA
  • Neonatal Lupus Erythematosus
    Anna Saenz de Cantele, Hospital University De Caracas, Venezuela

SYMPOSIA 7: Abuse and Factital Disease
Lawrence Schachner, University of Miami, USA
Ramon Grimalt, Universitat Internacional de Catalunya, Spain (chairs)

Child abuse and neglect, sexual abuse, and factitial injuries affect over 3 million children annually in the USA. That number is multiplied multifold worldwide. Environmental injuries to children’s skin exceeds those in number. This symposium will provide in depth education on these important issues.

  • Cutaneous Signs of Sexual Abuse
    Tor Shwayder, Henry Ford Hospital, USA
  • Skin Findings in Child Abuse
    Ramon Grimalt, Universitat Internacional de Catalunya, Spain
  • Environmental Injuries to Children's Skin
    Lawrence Schachner, University of Miami, USA
  • Dermatological Disorders Mimicking Abuse
    Jan Izakovic, Private Practice & University Children's Hospital, Basel, Switzerland
  • Factitial Disorders in Children
    Bernard Cohen, Johns Hopkins University, USA

SYMPOSIA 8: Cutaneous Manifestations of Endocrine Disorders in Children
Anne Lucky, Cincinnati Children's Hospital, USA
Eli Sprecher, Tel Aviv Sourasky Medical Center, Israel (chairs)

This symposium will cover various aspects of hormonal interactions in the skin. There will be a review of syndromic genodermatoses such as Carney complex, multiple endocrine neoplasias, autoimmune polyendocrinopathies, and Albright osteodystrophy. Disorders featuring androgen excess causing acne, hirsutism and androgenetic alopecia, including polycystic ovary syndrome, congenital adrenal hyperplasia and tumors, will be reviewed and mechanisms of androgen actions on the skin discussed. Finally there will be a presentation about some of the controversies surrounding the role of vitamin D as related to skin disorders.

  • Disorders of Androgen Excess
    Anne Lucky, Cincinnati Children's Hospital, USA
  • Vitamin D: Controversies in Diagnosis and Management
    Elaine Siegfried, St. Louis University, USA
  • Skin Manifestations of Syndromic Endocrine Disorders
    Elena Pope, The Hospital for Sick Children/University of Toronto, Canada

SYMPOSIA 9: Advances in Ichthyoses & Ichthyosis Syndromes
Keith Choate, Yale University School of Medicine, US
Heiko Traupe, University Hospital Muenster, Germany (chairs)

The aim of this symposium is to acquaint pediatric dermatologists with recent advances in the field of molecular diagnosis of ichthyosis, to familiarize attendees with the manifold practical problems that occur in the spectrum of peeling skin diseases (which encompas various disorders associated with skin peeling and allergic manifestations), and to review treatment for newborns and older children with congenital ichthyosis.

  • New Genes in Ichthyosis: Impact for the Pediatric Dermatologist
    Keith Choate, Yale University School of Medicine, USA
  • Clinical Spectrum and Pathogenesis of Peeling Skin Diseases
    Vinzenz Oji, University Hospital Muenster, Germany
  • Ichthyosis in the Newborn
    Brittany Craiglow, Yale University, USA
  • Therapies for Older Children with Congenital Ichthyoses
    Angela Hernandez-Martin, Hospital del Nino Jesus, Spain

3:30 pm – 4:00 pm
Break

4:00 pm – 5:30 pm

COURSE 2: Collagen Vascular Disorders: Integrating Research into Clinical Care – continued

SYMPOSIA 10: Updates on Hereditary Disorders of Elastic and Collagen Fibers (Pseudoxanthoma Elasticum, Cutis Laxa, Ehlers-Danlos Syndromes and Marfan Syndrome)
Jonathan Dyer, University of Missouri, USA
Ludovic Martin, Angers University Hospital, France (chairs)

Pseudoxanthoma elasticum (PXE), cutis laxa (CL), Ehlers-Danlos (EDS) and Marfan syndromes are hereditary disorders of elastic and collagen fibers. Each of these groups of disorders exhibits characteristic skin changes, even in childhood, which must be recognized by dermatologists and pediatricians. Recently, enormous progress in understanding these conditions has occurred. This session will succinctly review these disorders, focusing on critical clinical findings in childhood and state of the art updates regarding their evaluation and management, and highlight cutting edge advances in therapy.

  • Pseudoxanthoma Elasticum
    Ludovic Martin, Angers University Hospital, France
  • Cutis Laxa Syndromes
    Bert Callewaert, Ghent University Hospital, Belgium
  • Ehlers-Danlos Syndromes
    Jonathan Dyer, University of Missouri, USA
  • Marfan Disease and Related Disorders
    Smail Hadj-Rabia, Necker Enfants-Malades Hospital, France

SYMPOSIA 11: Inpatient and Critical Care Dermatology
Daniela Kroshinsky, Harvard Medical School/ Massachusetts General Hospital, USA
Jose Massimo, Latin American Society of Pediatric Dermatology - Argentine Association of Pediatric Dermatology, Argentina (chairs)

Inpatient dermatology provides an opportunity to longitudinally manage complex cases in pediatric dermatology and the dermatologist is an important member of the team caring for hospitalized children. This session will examine several challenging clinical scenarios in a case-based format and provide the attendee with an understanding of current and evolving standards of care. Common serious problems and their uncommon manifestations will be discussed. Interesting and rare examples of severe skin conditions will be presented. Valuable diagnostic and therapeutic interventions will be reviewed. This session is geared toward physicians caring for inpatients as well as treating complex patients presenting to the office.

  • Challenging Inpatient Cases - Always Learning!
    Lawrence Eichenfield, Rady Children's Hospital, San Diego/UCSD, USA
  • Neonatal and Infantile Consultative Dermatology
    Sharon Glick, State University of New York, Downstate Medical Center, USA
  • Acute Skin Failure
    Ianina Massimo, Latin American Society of Pediatric Dermatology - Argentine Association of Pediatric Dermatology, Argentina
  • Skin Manifestations of Sepsis
    Pedro Zubillaga, Latin American Society of Pediatric Dermatology - Argentine Association of Pediatric Dermatology, Argentina

SYMPOSIA 12: Evidence Based Management of Pediatric Psoriasis
Kelly Cordoro, University of California San Francisco, USA
Marieke Seyger, Radboud University Nijmegen Medical Centre, Netherlands (chairs)

Evidence-based practice integrates clinical expertise and high quality research evidence into the decision making process. Optimal management of pediatric psoriasis therefore requires a combination of up-to-date knowledge of the best available evidence, clinical experience, consideration of family preferences and understanding of disease impact on quality of life. In this symposium, international experts will summarize current evidence and offer their clinical expertise on genetic discoveries, potential comorbidities, use of conventional systemic treatments and biologic therapies relevant to the care of childhood psoriasis.

  • New World View of Pustular Psoriasis: Genetic Advances and Clinical Approach
    Amy Paller, Northwestern University, USA
  • Comorbidities in Children with Psoriasis: Recognition and Screening
    Kelly Cordoro, University of California San Francisco, USA
  • Conventional Systemic Treatments: Old-Fashioned or Up-to-Date?
    Marieke Seyger, Radboud University Nijmegen Medical Centre, Netherlands
  • Hitting the Target: Treatment of Severe Disease with Biologic Therapy
    Irene Lara-Corrales, University of Toronto/Hospital for Sick Children, Canada

5:30 pm – 7:00 pm
Formal Poster Session

>continue to Saturday, July 8